Endocrine Abstracts

Introduction: The majority of adrenocortical incidentalomas (AIs) are nonfunctional adenomas. Some of them demonstrate an autonomous cortisol secretion (ACS), a pathologic condition defined as biochemical evidence of hypercortisolism without typical signs or symptoms of Cushing’s syndrome.Subjects and methods: In this cross-sectional study, we evaluated 152 consecutive patients, aged 58.3 years (range, 25-84 years) of whom 105 (69.1%) with unilatera...

Introduction: Multiple endocrine neoplasia type 2 is an autosomal dominant polyglandular cancer syndrome. It arises as a result of a germline mutation of the RET proto-oncogene. The aim of this study was to evaluate the aggressiveness of medullary thyroid carcinoma (MTC) in patients with a proven germline mutation in codon 634 RET proto-oncogene, the occurrence of other associated diseases and survival analysis.Methods: The retrospectiv...

Introduction: Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy among women during reproductive age. PCOS cardinal manifestations include hyperandrogenism, oligo/anovulation, and/or polycystic ovarian morphology, and is closely linked to metabolic disorders such as obesity and insulin resistance (IR). It was observed that single-point insulin sensitivity estimator (SPISE) index is associated with metabolic abnormalities and could predict glucose regulation ...

Introduction: Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy among women during reproductive age. Using ESHRE/ASRM diagnosis of PCOS is considered when 2 of 3 criteria are present: polycystic ovary morphology (PCOM), oligo/anovulation (ANOV) and hyperandrogenism (HA). These criteria form four different phenotypes: A (ANOV, HA, PCOM), B (ANOV, HA), C (HA, PCOM) and D (ANOV, PCOM). Several studies have found differences in anthropometric, hormonal and meta...

Introduction: Polycystic ovarian syndrome (PCOS) is characterized by hyperandrogenism, chronic oligo-/anovulation and polycystic ovarian morphology. Hyperandrogenism is a key diagnostic feature of PCOS and according to ESHRE/ASRM criteria it can be clinical and/or biochemical. SPISE index (single-point insulin sensitivity estimator index) is a new indicator of insulin sensitivity and a predictor of abnormal glucose metabolism. The aim of the research was to analyse association...

Interindividual variations in tissue sensitivity to glucocorticoids (GC) have been partly attributed to polymorphisms in the glucocorticoid receptor (GR) gene. The aim of this study was to investigate whether BclI variant of the GR gene may contribute to metabolic abnormalities frequently present in patients with adrenal incidentaloma (AI). Biochemical tests and hormonal evaluation were performed in 106 consecutive women with AI. Non-diabetic patients underwent an ora...

Neuroendocrine tumors encompass a heterogeneous group of tumors arising from the diffuse neuroendocrine system. The incidence of NETs rises with age, with the peak after 65 years. However, all NETs observed in adults may be diagnosed in children too. There are a very few studies addressing NETs in young patients. This study summarizes clinical, histopatological and genetic characteristics of young patients with NETs. This is a retrospective study describing clinical, histopath...

Introduction: Although intensive, repeated and perennial, physical stress of training generally does not represent a health hazard to professional athletes. Adaptation to such stress is presumed on multiple levels, but still not fully defined. Our aim was to analyze specificities of hypothalamic-pituitary-adrenal (HPA) axis response and adaptation to physical stress in professional athletes.Subjects and methods: We exposed 55 professional male athletes t...

Introduction and aims: Autoimmune thyroiditis represent a state predisposed for the development of hypothyroidism. It is known that subclinical and overt hypothyroidism are important risk factors associated with the development and progression of heart failure. These effects are due to the changes in the structure and function of the cardiac muscle, as well as the overall cardiac mechanics. The aim of our study was to examine the influence of autoimmune thyroiditis (Hashimoto ...

Introduction: Metformin and oral contraceptive pills (OCP) are the most commonly prescribed medications among women with polycystic ovary syndrome (PCOS). The aim of this study was to compare effects of pill containing cyproterone-acetate (CPA) and metformin (METF) in women with PCOS during six months of follow-up.Methods: Group of 60 women with PCOS diagnosed by ESHRE/ASRM criteria were divided into 3 subgroups (20 women each), which were treated with d...